Linkage and Gene Map

Gene mapping - A genetic map refers to the assignment of DNA fragments to chromosomes. When a genome is first investigated, this map is non existent.

Y linkage - In mammals, Y-linkage refers to when a phenotypic trait is determined by an allele (or gene) on the Y chromosome.

Genetic linkage - Genetic linkage occurs when particular alleles are inherited together. Typically, an organism can pass on an allele without regard to which allele was passed on for a different gene.

GRK3 - In 2003, a group of American and Canadian researchers published a paper that used gene linkage techniques to identify a mutation in the GRK3 gene as a possible cause of up to 10% of cases of bipolar disorder. This gene is associated with a kinase enzyme called G protein receptor kinase 3, which appears to be involved in dopamine metabolism, and may provide a possible target for new drugs for bipolar disorder.

linkageandgenemap

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